+ 44 28 9097 6474 V.Tiwari@qub.ac.uk

Research Interests Epigenetic Regulation of Differentiation and Disease

We are particularly interested in studying how cell-fates are specified during developmentand miss-specified in diseases.

The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis.

Researches The Key Topics of Research

  • Transcription Factors and Cell-Fate Specification
  • Epigenomics of Cell-type Identity
  • Signaling to Chromatin Crosstalk
  • Epigenetic Regulation of Neurogenesis
  • Chromatin and Cancer
  • Systems Biology of Gene Regulatory Networks