+ 44 28 9097 6474 V.Tiwari@qub.ac.uk

Most relevant publications

  •  

Stage-SpecificTranscription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes Tiwari N, Pataskar A, Péron S, Thakurela S, Sahu SK, Figueres-Oñate M,Marichal N, López-Mascaraque L, Tiwari VK*, Berninger B*(*co-corresponding authors) Cell Stem Cell, 2018,Oct4;23(4):557

  •  

FBXO32 promotes microenvironment underlying Epithelial-Mesenchymal Transition via CtBP1 during tumor metastasis and brain development Sahu S, Tiwari N, Pataskar A,Borisova M, Diken M, Strand S, Beli P, Tiwari VK*(*corresponding author) Nature Communications, 2017,Nov 15;8(1):1523

  •  

NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. Pataskar A, Jung J, Smialowski P, Calegari F, Straub T, Tiwari VK*(*corresponding author) The EMBO Journal, 2016 Jan 4;35(1):24-45 (Featured article, see news & views by Glahs&Zinzen:The EMBO Journal, 2016 Jan 4;35(1):1-3) (Rated “Exceptional” by Faculty of 1000)

  •  

Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity. Thakurela S, Sahu SK, Garding A, Tiwari VK*(*corresponding author) Genome Research, 2015 Sep;25(9):1309-

  •  

JNK-dependent gene regulatory circuitry governs mesenchymal fate. Sahu SK, Garding A, Berninger B, Nitsch R, Schmidt M, Tiwari VK*(*corresponding author) The EMBO Journal, 2015 Aug 13;34(16):2162-81.  

  •  

Gene Regulation and Priming by Topoisomerase IIα in embryonic stem cells.

Thakurela S, Garding A, Jung, Schübeler D, Burger L, Tiwari VK* (*corresponding author)

Nature Communications, 2013, Sep 27; 4:2478

  •  

Target genes of Topoisomerase IIbeta regulate neuronal survival and are defined by their chromatin state Tiwari VK*,Burger L, Nikoletopoulou V, Deogracious R, Thakurela S, Wirbelauer C, Hoerner L, Mielke C, Boege F, Murr R, Peters A, Barde YA, Schübeler D* (*co-corresponding authors) PNAS,2012 Apr 17;109(16):E934-43

  •  

A Chromatin-modifying Function of JNK during Stem Cell Differentiation. Tiwari VK, Stadler M, Wirbelauer C, Paro R, Beisel C, Schübeler D Nature Genetics,2012 Jan 18;44(1):94-100  (Featured in Faculty of 1000, medical express and bioportfolio)

  •  

A Chromatin-modifying Function of JNK during Stem Cell Differentiation. Tiwari VK, Stadler M, Wirbelauer C, Paro R, Beisel C, Schübeler D Nature Genetics,2012 Jan 18;44(1):94-100 (Featured in Faculty of 1000, medical express and bioportfolio)

  •  

DNA-binding factors shape the mouse methylome at distal regulatory regions. Stadler MB, Murr R, Burger L, Ivanek R, Lienert F, Schöler A, Nimwegen E, Wirebeluer C, Oakeley EJ, Gaidatzis D, Tiwari VK, Schübeler D. Nature,2011 Dec 14;480(7378):490-5

  •  

PcG Proteins, DNA methylation and gene repression by chromatin looping. Tiwari VK, McGarvey KM, Licchesi J, Ohm JE, Herman JG, Schübeler D, Baylin SB PLoS Biology, 2008 Dec 2; 6(12):2911-27 (“Editor’s choice”, see: PLoS Biol. 2008 December; 6(12): e313, by Mary Hoff)

  •  

A Novel 6C assay uncovers polycomb-mediated higher order chromatin conformations. Tiwari VK, Cope L, McGarvey KM, Ohm JE, Baylin SB Genome Research, 2008 Jul; 18(7): 1171-9 (IF= Impact Factor)

Rest of the publications

  •  

Direct Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis. Noack F, Pataskar A, Schneider M, Buchholz F, Tiwari VK, Calegari F. Life Sci Alliance.2019 Feb 27;2(2). pii: e201900331.

  •  

The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Bräuninger M, Nguyen L, Götz M. Nature,2019 Mar;567(7746):113-117.

  •  

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, Casamassa A, Smiyakin A, Schichor C, Götz M, Tiwari VK, Treutlein B, Berninger B. Nature Neurosci. 2018Jun 18. doi: 10.1038/s41593-018-0168-3.

  •  

Exploring the Complexity of Cortical Development Using Single-Cell Transcriptomics. Jeong H, Tiwari VK*. (*corresponding author) Front Neurosci.,2018 Feb 2;12:31.

  •  

ERK signalling modulates epigenome to drive epithelial to mesenchymal transition. Navandar M, Garding A, Sahu SK, Pataskar A, Schick S, Tiwari VK*. (*corresponding author) Oncotarget, 2017Apr 25;8(17):29269-29281.

  •  

Genetic labelling of nuclei-specific thalamocortical neurons reveals putative sensory-modality specific genes. Gezelius H, Moreno-Juan V, Mezzera C, Pistolic J, Benes B, Tiwari VK, López-Bendito G. Cerebral Cortex, 2017Nov 1;27(11):5054-5069.       

  •  

The transcriptome of mouse central nervous system myelin. Thakurela S, Garding A, Jung RB, Müller C, Goebbels S, White R, Werner H*, Tiwari VK* (*co-corresponding authors) Nature Scientific Reports, 2016May 13;6:25828.      

  •  

TOX3 regulates neural progenitor identity. Sahu SK, Fritz A, Tiwari N, Kovacs Z, Pouya A, Wüllner V, Bora P, Schacht T, Baumgart J, Peron S, Berninger B,Tiwari VK*, Methner A*(*co-corresponding authors) BBA Gene Regulatory Mechanisms, 2016 Apr 11;1859(7):833-840.

  •  

Computational challenges in modeling gene regulatory networks. Pataskar A,Tiwari VK*. (*corresponding author) Transcription, 2016

  •  

Deciphering the epigenetic code of embryonic neurogenesis. Pataskar A, Jung J, Tiwari VK*. (*corresponding author) Encyclopedia of Molecular Cell Biology and Molecular Medicine (Wiley), 2016

  •  

Mapping gene regulatory circuitry of Pax6 during neurogenesis.  Thakurela S, Tiwari N, Schick S, Garding A, Berninger B and Tiwari VK* (*corresponding author) Cell Discovery, 2016 2, 15045.

  •  

Chromatin Immunoprecipitation Assay to Identify Genomic Binding Sites of Regulatory Factors. Wagner M, Jung J, Koslowski M, Türeci Ö, Tiwari VK*, Sahin U*. (*co-corresponding authors) Methods Mol Biol. 2016;1366:53-65. doi: 10.1007/978-1-4939-3127-9_6.

  •  

Identifying Novel Transcriptional Regulators with Circadian Expression. Schick S*, Becker K*, Thakurela S, Fournier D, Hampel MH, Legewie S*, Tiwari VK*(*co-corresponding authors). Mol Cell Biol, 2016 36, 545-58.

  •  

Distinct roles of Hand2 in developing and adult autonomic neurons. Stanzel S, Stubbusch J, Pataskar A, Ernsberger U, Tiwari VK, Rohrer H, Tsarovina K. Developmental Neurobiology, 2016 Jan 28. doi: 10.1002/dneu.22378.

  •  

Dynamics of chromatin accessibility and epigenetic state in response to UV damage. Schick S, Fournier D, Thakurela S, Sahu SK, Garding A, Tiwari VK*(*corresponding author) Journal of Cell Science, 2015: doi: 10.1242/jcs.173633

  •  

Prakash K, Fournier D, Redl S, Best G, Borsos M, Tiwari VK, Ketting R, Tachibana-Konwalski K, Cremer C and Birk U (2015). Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes. PNAS, 2015 112, 14635-14640

  •  

The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1.  von der Lippen C, Sahu SK, Seifermann M, Tiwari VK and Epe B. DNA Repair, 2015 25, 1-8

  •  

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.  Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, Serra L, Thakurela S, Tiwari VK, Weichenhan D, Benner A, Radlwimmer B, Zentgraf H, Wiemann S, Rippe K, Plass C, Döhner H, Lichter P, Stilgenbauer S and Mertens D (2013). PLoS Genet, 9, e1003373

  •  

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming.  Tiwari N, Tiwari VK, Waldmeier L, Balwierz P, Arnold P, Pachkov M, Meyer-Schaller N, Schübeler D, van Nimwegen E and Christofori G (2013). Cancer Cell, 2013 23, 768-783

  •  

Dynamics and determinants of DNA accessibility. Bell O, Tiwari VK, Thomä NH and Schübeler D. Nature Reviews Genetics 2011, 12, 554-564.

  •  

Genomic Prevalence of Heterochromatic H3K9me2 and Transcription Do Not Discriminate Pluripotent from Terminally Differentiated Cells. Lienert F, Mohn F, Tiwari VK, Baubec T, Roloff TC, Gaidatzis D, Stadler MB and Schubeler D. PLOS Genet, 2011 7, e1002090. 

  •  

Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc. Licchesi JD, Van Neste L, Tiwari VK, Cope L, Lin X, Baylin SB and Herman JG. Oncogene, 2011 29, 5923-5934.

  •  

Mapping networks of protein-mediated physical interactions between chromatin elements. Tiwari VK* and Baylin SB*. (*co-corresponding authors) Curr Protoc Mol Biol, 2010Chapter 21, Unit 21 16 1-13.

  •  

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development. Sandhu KS, Shi C, Sjölinder M, Liu L, Tiwari VK, Guibert S, Emilsson L, Imreh MP and Ohlsson R. Genes Dev, 2009 23, 2598-2603.       

  •  

Combined 3C-ChIP-cloning (6C) assay: a tool to unravel protein-mediated genome architecture.Tiwari VK* and Baylin SB*. (*co-corresponding authors) Cold Spring Harb Protoc, 2009 pdb prot5168.

  •  

Breaching the boundaries that safeguard against repression. Tiwari VK and Baylin SB. Mol Cell,  2009 34, 395-397.       

  •  

Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes. Nemeth A, Guibert S, Tiwari VK, Ohlsson R and Langst G. EMBO J,2008 27, 1255-1265.

  •  

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Tiwari VK*,  Kurukuti S*, Tavoosidana G *, Pugacheva E, Murrell A, Zhao Z, Lobanenkov V, Reik W and Ohlsson R. (* indicates equal contribution) PNAS, 2006 103, 10684-10689.

  •  

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Zhao Z, Tavoosidana G, Sjolinder M, Gondor A, Mariano P, Wang S, Kanduri C, Lezcano M, Singh Sandhu K, Singh U, Pant V, Tiwari VK, Kurukuti S and Ohlsson R (2006). Nat Genet, 2006 38, 1341-1347.

  •  

Burke LJ*, Zhang R*, Bartkuhn M*, Tiwari VK, Tavoosidana G, KurukutiS, Weth C, Leers J, Galjart N, Ohlsson R and Renkawitz R (2005). CTCF binding and higher order structure of Igf2-H19 locus is conserved through mitosis. (* indicates equal contribution) EMBO J, 2005 24, 3291-3300.

  •  

Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation. Pugacheva EM, Tiwari VK, Abdullaev Z, Vostrov AA, Flanagan PT, Quitschke WW, Loukinov DI, Ohlsson R and Lobanenkov VV (2005). Hum Mol Genet, 2005 14, 953-65.

  •  

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Tiwari VK*, Thakur N*, Thomassin H, Pandey RR, Kanduri M, Gondor A, Grange T, Ohlsson R and Kanduri C (2004). (* indicates equal contribution) Mol Cell Biol, 2004 24, 7855-62.